PAMAfrica PhD student poster presentations at the ASTMH Annual Meeting
Two PAMAfrica students will be attending this year's ASTMH Annual Meeting to share their research during the poster presentation sessions. We're happy to announce that Victor Asua and Francis Bohissou will both take part in Poster session B on Tuesday, 11 November at 12:00 PM (Hall E). Whether you're a fellow researcher, clinician, policymaker or student, join them to discuss their work and see how it’s contributing to the malaria elimination agenda. See the poster titles and overviews below.
Victor Ausa: Clonal expansion and rapid spread of PfDHFR 164L underlie the evolving landscape of antifolate resistance in P. falciparum across Uganda
Antifolate resistance in Plasmodium falciparum, driven by mutations in the pfdhfr and pfdhps genes, poses a persistent threat to malaria control, especially where sulfadoxine-pyrimethamine remains in use for chemoprevention.
Yet, the evolutionary dynamics and spatial patterns of resistance mutations remain incompletely understood in East Africa. This study performed longitudinal genomic surveillance of P. falciparum across 16 sites in Uganda from 2016 to 2022. A total of 4,725 field isolates were sequenced at 11 resistance-associated loci in pfdhfr and pfdhps.
Visit the ASTMH poster presentation page for more info.
Francis Bohissou: Temporal trends in the prevalence of Pfcrt and Pfmdr1 mutations in sub-Saharan Africa, 2010-2024: a systematic review and meta-analysis
The emergence and spread of antimalarial drug resistance threaten the efficacy of Artemisinin-based Combination Therapies (ACTs) in sub-Saharan Africa. While mutations in PfKelch13 are linked to partial artemisinin resistance, mutations in Pfcrt and Pfmdr1, associated with resistance to partner drugs such as amodiaquine and lumefantrine, pose a significant concern.
We conducted a systematic review and meta-analysis of studies published from 2010 to 2024, searching PubMed/MEDLINE and Scopus. Two independent reviewers assessed eligibility, extracted data, and evaluated bias. A total of 182 studies on Pfcrt and 196 on Pfmdr1 were included.
Visit the ASTMH poster presentation page for more info.